The use of the Barycela vaccine in one- or two-dose schedules for children is fully appropriate. Photo: NAVIVA GROUP<\/span><\/i><\/span><\/p>\n In the latest WHO guidelines on varicella vaccination, published in November 2025, a two-dose vaccination schedule is recommended to achieve optimal protection against varicella.<\/span><\/p>\n Results from studies cited as evidence for this recommendation demonstrate a significant increase in effectiveness with a two-dose schedule compared to a single-dose regimen.<\/span><\/p>\n With only one dose, varicella vaccine effectiveness reaches approximately 95% [1]. In contrast, with a two-dose schedule, vaccine effectiveness increases to 100% [2].<\/span><\/p>\n In this document, WHO also emphasizes that countries currently implementing a one-dose varicella vaccination schedule should note that such programs are primarily sufficient to reduce mortality and severe disease, rather than to fully prevent virus circulation and outbreaks.<\/span><\/p>\n A one-dose schedule is therefore less effective in preventing viral transmission and varicella outbreaks. The second dose should be administered at an interval of at least four weeks after the first dose. Older children and adults should also receive this booster dose to achieve optimal immunity.<\/span><\/p>\n The updated WHO guidance further confirms that the safety and immunogenicity of the MAV\/06 strain varicella vaccine\u2014commercially known as Barycela\u2014are comparable to those of Oka strain varicella vaccines commonly used in current commercial products [3,4].<\/span><\/p>\n Long-term use of the Barycela vaccine in the National Immunization Program of South Korea, as well as in several other countries, has demonstrated a marked reduction in varicella incidence, including a decrease in cases of herpes zoster (shingles) among vaccinated children [5].<\/span><\/p>\n![\"\"](\"https:\/\/naviva.com.vn\/wp-content\/uploads\/2025\/12\/Anh-2.jpg\")
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