{"id":2939,"date":"2026-03-10T13:36:14","date_gmt":"2026-03-10T06:36:14","guid":{"rendered":"https:\/\/naviva.com.vn\/?p=2939"},"modified":"2026-05-12T13:59:22","modified_gmt":"2026-05-12T06:59:22","slug":"mav-06-varicella-vaccine-and-its-safe-interchangeability","status":"publish","type":"post","link":"https:\/\/naviva.com.vn\/en\/mav-06-varicella-vaccine-and-its-safe-interchangeability","title":{"rendered":"MAV\/06 VARICELLA VACCINE AND ITS SAFE INTERCHANGEABILITY"},"content":{"rendered":"

Varicella is a highly contagious disease with the potential to cause outbreaks and serious complications. Vaccination is the most effective measure for prevention.<\/span><\/p>\n

\"\"<\/a>Varicella vaccination for children Photo: Naviva Group<\/span><\/p>\n

Currently available varicella vaccines worldwide contain one of two live attenuated virus strains: Oka or MAV\/06.<\/span><\/p>\n

The MAV\/06 strain, developed in the Republic of Korea, has been used for over 30 years, with tens of millions of doses administered, demonstrating well-established safety and effectiveness.<\/span><\/p>\n

From a scientific perspective, the MAV\/06 and Oka strains are genetically similar and belong to the same clade of the varicella-zoster virus. Therefore, immunity induced by MAV\/06-containing vaccines is capable of recognising and effectively neutralising different VZV strains, including the Oka strain [1]. The immune response elicited by MAV\/06-based vaccines is comparable to that of Oka-based vaccines [2].<\/span><\/p>\n

Real-world data further demonstrate the effectiveness of MAV\/06-based vaccines in the Republic of Korea, where this strain is exclusively used in the National Immunization Program, showing outcomes equivalent to countries using Oka-based vaccines.<\/span><\/p>\n

Notably, in children who receive the full two-dose schedule, including those who receive interchangeable doses between MAV\/06 and Oka strains, no increased risk of disease or complications has been observed [3].<\/span><\/p>\n

The World Health Organization (WHO) has recognised the comparable effectiveness of MAV\/06 and Oka strains and allows interchangeability of varicella vaccines when necessary, particularly for booster doses. This provides greater flexibility in immunisation schedules [4].<\/span><\/p>\n

Thus, MAV\/06-containing varicella vaccines are not merely an alternative, but a scientifically and clinically equivalent option, contributing to sustained effectiveness in varicella prevention.<\/span><\/p>\n\n\n\n
BARYCELA Inj., a next-generation varicella vaccine developed by GC Biopharma from the MAV\/06 strain, demonstrates immunogenicity and safety comparable to Oka-based vaccines and can be used within current two-dose immunisation schedules [10].<\/span>
\n<\/span> Recommended two-dose schedule for optimal immunity<\/span><\/span><\/p>\n

Children aged 12 months to 12 years:<\/span><\/p>\n

\u2013 Dose 1: from 12 months of age.<\/span><\/p>\n

\u2013 Dose 2: at least 3 months after Dose 1, or a booster dose at 4\u20136 years of age.<\/span><\/p>\n

In Viet Nam, NAVIVA GROUP is the authorised distributor of the second-generation MAV\/06 varicella vaccine, marketed as BARYCELA inj. (GC Biopharma \u2013 Republic of Korea). With more than 21 years of experience in vaccines and medical biological products, NAVIVA GROUP collaborates with healthcare facilities to enhance access to safe, effective, and high-quality vaccines for the community.<\/span><\/p>\n

The company is committed to ensuring a stable supply and strict compliance with storage and distribution processes in accordance with GSP\/GDP standards, while actively supporting initiatives to raise awareness of proactive and safe immunisation.<\/span><\/p>\n

\ud83d\udcde Hotline: 0905 584 666<\/span><\/p>\n

\ud83c\udf10 Website<\/span>:<\/span> www.naviva.com.vn<\/span><\/a><\/p>\n

\ud83d\udce7 Email: info@naviva.com.vn<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

References<\/span><\/p>\n

    \n
  1. Hwang JY, et al. Cross-reactive humoral immunity of clade 2 Oka and MAV\/06 strain-based varicella vaccines against different clades of varicella-zoster virus. Hum Vaccin Immunother. 2023 Dec 31;19(1):2210961.<\/span><\/li>\n
  2. Choi UY, et al. Seropositivity of Varicella zoster virus in vaccinated Korean children and MAV vaccine group. Hum Vaccin Immunother. 2016 Oct 2;12(10):2560\u20132564.<\/span><\/li>\n
  3. Kang, H.M.; Kim, G.; Choe, Y.J. Safety of Interchanging the Live Attenuated MAV\/06 Strain and OKA Strain Varicella Vaccines in Children. Vaccines. 2023;11:1442.<\/span><\/li>\n
  4. WHO position paper on varicella vaccines \u2013 November 2025.<\/span><\/li>\n<\/ol>\n

    source:<\/span> laodong.vn<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

    Varicella is a highly contagious disease with the potential to cause outbreaks and serious complications. Vaccination is the most effective measure for prevention. Varicella vaccination for children Photo: Naviva Group Currently available varicella vaccines worldwide contain one of two live attenuated virus strains: Oka or MAV\/06. The MAV\/06 strain, developed in the Republic of Korea, […] <\/p>\n","protected":false},"author":4,"featured_media":2788,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[25],"tags":[],"class_list":["post-2939","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"acf":[],"_links":{"self":[{"href":"https:\/\/naviva.com.vn\/en\/wp-json\/wp\/v2\/posts\/2939","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/naviva.com.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/naviva.com.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/naviva.com.vn\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/naviva.com.vn\/en\/wp-json\/wp\/v2\/comments?post=2939"}],"version-history":[{"count":2,"href":"https:\/\/naviva.com.vn\/en\/wp-json\/wp\/v2\/posts\/2939\/revisions"}],"predecessor-version":[{"id":2941,"href":"https:\/\/naviva.com.vn\/en\/wp-json\/wp\/v2\/posts\/2939\/revisions\/2941"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/naviva.com.vn\/en\/wp-json\/wp\/v2\/media\/2788"}],"wp:attachment":[{"href":"https:\/\/naviva.com.vn\/en\/wp-json\/wp\/v2\/media?parent=2939"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/naviva.com.vn\/en\/wp-json\/wp\/v2\/categories?post=2939"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/naviva.com.vn\/en\/wp-json\/wp\/v2\/tags?post=2939"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}