{"id":3043,"date":"2026-06-29T14:29:57","date_gmt":"2026-06-29T07:29:57","guid":{"rendered":"https:\/\/naviva.com.vn\/?p=3043"},"modified":"2026-06-29T14:42:34","modified_gmt":"2026-06-29T07:42:34","slug":"tinh-on-dinh-cua-vac-xin-thuy-dau-the-he-2-chung-mav-06-barycela-gia-tri-tu-du-lieu-khoa-hoc-den-thuc-hanh-tiem-chung","status":"publish","type":"post","link":"https:\/\/naviva.com.vn\/en\/tinh-on-dinh-cua-vac-xin-thuy-dau-the-he-2-chung-mav-06-barycela-gia-tri-tu-du-lieu-khoa-hoc-den-thuc-hanh-tiem-chung","title":{"rendered":"T\u00ednh \u1ed5n \u0111\u1ecbnh c\u1ee7a v\u1eafc xin th\u1ee7y \u0111\u1eadu th\u1ebf h\u1ec7 2 ch\u1ee7ng MAV\/06 – Barycela: Gi\u00e1 tr\u1ecb t\u1eeb d\u1eef li\u1ec7u khoa h\u1ecdc \u0111\u1ebfn th\u1ef1c h\u00e0nh ti\u00eam ch\u1ee7ng"},"content":{"rendered":"

\u0110\u1ed1i v\u1edbi c\u00e1c v\u1eafc xin s\u1ed1ng gi\u1ea3m \u0111\u1ed9c l\u1ef1c, t\u00ednh \u1ed5n \u0111\u1ecbnh l\u00e0 m\u1ed9t trong nh\u1eefng y\u1ebfu t\u1ed1 quan tr\u1ecdng quy\u1ebft \u0111\u1ecbnh ch\u1ea5t l\u01b0\u1ee3ng s\u1ea3n ph\u1ea9m trong su\u1ed1t qu\u00e1 tr\u00ecnh b\u1ea3o qu\u1ea3n, v\u1eadn chuy\u1ec3n v\u00e0 s\u1eed d\u1ee5ng. B\u1edfi virus s\u1ed1ng c\u00f3 th\u1ec3 gi\u1ea3m ho\u1ea1t l\u1ef1c theo th\u1eddi gian ho\u1eb7c khi ti\u1ebfp x\u00fac v\u1edbi c\u00e1c \u0111i\u1ec1u ki\u1ec7n b\u1ea3o qu\u1ea3n kh\u00f4ng t\u1ed1i \u01b0u.<\/span><\/p>\n

V\u1eafc xin th\u1ee7y \u0111\u1eadu th\u1ebf h\u1ec7 2 ch\u1ee7ng MAV\/06 – Barycela \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n v\u1edbi nhi\u1ec1u c\u1ea3i ti\u1ebfn trong quy tr\u00ecnh s\u1ea3n xu\u1ea5t, \u0111\u1ed3ng th\u1eddi \u0111\u01b0\u1ee3c h\u1ed7 tr\u1ee3 b\u1edfi c\u00e1c d\u1eef li\u1ec7u \u1ed5n \u0111\u1ecbnh \u0111\u00e1ng ch\u00fa \u00fd.<\/span><\/p>\n

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H\u00ecnh \u1ea3nh: V\u1eafc xin th\u1ee7y \u0111\u1eadu Barycela<\/em><\/span><\/p>\n

Duy tr\u00ec hi\u1ec7u gi\u00e1 t\u1ed1i thi\u1ec3u 3.800 PFU trong su\u1ed1t th\u1eddi h\u1ea1n s\u1eed d\u1ee5ng<\/strong><\/span><\/h2>\n

Barycela duy tr\u00ec t\u1ed1i thi\u1ec3u 3.800 PFU (Plaque Forming Units) trong to\u00e0n b\u1ed9 th\u1eddi h\u1ea1n s\u1eed d\u1ee5ng 24 th\u00e1ng. \u0110\u00e2y l\u00e0 m\u1ee9c hi\u1ec7u gi\u00e1 t\u1ed1i thi\u1ec3u cao h\u01a1n so v\u1edbi m\u1ed9t s\u1ed1 v\u1eafc xin th\u1ee7y \u0111\u1eadu ch\u1ee7ng Oka \u0111ang \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng tr\u00ean th\u1ebf gi\u1edbi (1).<\/span><\/p>\n\n\n\n\n\n
\u00a0<\/strong><\/span><\/td>\nMAV\/06 th\u1ebf h\u1ec7 2<\/strong><\/span><\/td>\nOka\/Merck<\/strong><\/span><\/td>\nOka\/RIT<\/strong><\/span><\/td>\n<\/tr>\n
H\u1ea1n d\u00f9ng<\/strong><\/span><\/td>\n24 th\u00e1ng<\/span><\/td>\n24 th\u00e1ng<\/span><\/td>\n24 th\u00e1ng<\/span><\/td>\n<\/tr>\n
Gi\u00e1 tr\u1ecb PFU t\u1ed1i thi\u1ec3u<\/strong><\/span><\/td>\n3800<\/span><\/td>\n1350<\/span><\/td>\n1995<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

B\u1ea3ng: So s\u00e1nh gi\u00e1 tr\u1ecb PFU t\u1ed1i thi\u1ec3u gi\u1eefa c\u00e1c lo\u1ea1i v\u1eafc xin ph\u00f2ng b\u1ec7nh th\u1ee7y \u0111\u1eadu<\/em><\/span><\/p>\n

Trong nghi\u00ean c\u1ee9u pha III \u0111a trung t\u00e2m. K\u1ebft qu\u1ea3 cho th\u1ea5y v\u1eafc xin Barycela \u0111\u1ea1t ti\u00eau ch\u00ed kh\u00f4ng thua k\u00e9m (non-inferior) so v\u1edbi v\u1eafc xin Oka\/Merck v\u1ec1 t\u00ednh sinh mi\u1ec5n d\u1ecbch v\u00e0 t\u00ednh an to\u00e0n sau ti\u00eam (2).<\/span><\/p>\n

D\u1eef li\u1ec7u \u1ed5n \u0111\u1ecbnh \u1edf \u0111i\u1ec1u ki\u1ec7n 15\u00b0C trong 28 ng\u00e0y<\/strong><\/span><\/h2>\n

Trong nghi\u00ean c\u1ee9u \u1ed5n \u0111\u1ecbnh c\u1ee7a nh\u00e0 s\u1ea3n xu\u1ea5t, Barycela \u0111\u01b0\u1ee3c b\u1ea3o qu\u1ea3n \u1edf \u0111i\u1ec1u ki\u1ec7n:<\/span><\/p>\n